Michael Caligiuri
Michael P. Caligiuri, Ph.D.
University of California, San Diego
Department of Psychiatry
9500 Gilman Drive (0603)
La Jolla, CA 92093
Phone #: 858-455-5050
FAX #: 858-455-9540


Dr. Caligiuri attended the University of Wisconsin, Madison where he received a Ph.D. in neuroscience with an emphasis in motor control. Upon completion of this work in 1986, he accepted a post-doc position in San Diego where he started a movement disorders laboratory for studying levodopa-induced dyskinesia in Parkinson’s disease. Dr. Caligiuri began working with faculty in the Department of Psychiatry in 1987 to test novel instruments for quantifying tardive dyskinesia and drug-induced parkinsonism.

Research Focus

Dr Caligiuri’s major research themes of his research include design and development of instrumentation for assessing extrapyramidal movement disorders, psychophysiology, and psychopharmacology with particular emphasis on medication responses in psychosis patients. He has been the principle investigator on several federally funded research projects focusing on quantifying drug-induced movement disorder to better understand psychopathology and treatment response. He has been involved in novel studies of brain functional MRI to identify neural circuits underlying depression and mania. Dr Caligiuri has authored over 100 peer-reviewed articles in medical journals and book chapters on the topic of movement disorders, brain imaging, and biomedical instrument development.

Clinical Focus

Dr. Caligiuri’s clinical focus is on movement disorders with particular emphasis on tardive dyskinesia, and drug-induced parkinsonism He is involved in the residency- training program as a lecturer on movement disorders and consultant to inpatient psychiatry house-staff.


He currently serves as the Director of the Human Research Protections Program at UCSD, a position he has held since 2005. This program oversees the ethical and regulatory aspects of all research involving human subjects and includes 5 Institutional Review Boards (or IRBs) represented by over 50 faculty and community board members and currently monitors the ethical and regulatory conduct of over 3500 active research studies at UCSD including several hundred FDA-regulated trials.

Selected Publications

Caligiuri MP, Lohr JB, Jeste DV (1993) Parkinsonism in neuroleptic-naïve schizophrenic patients Am J Psychiat 150:1343-1348

Caligiuri MP, Lohr JB, Ruck, RK (1998) Scaling of movement velocity: a measure of neuromotor retardation in individuals with psychopathology Psychophysiology 35: 431-437

Caligiuri MP, Ellwanger J. (2000) Motor and cognitive aspects of motor retardation in depression. J Affective Disorders, 57: 83-93

Caligiuri MP, Tripp MP (2004) A portable hand-held device for quantifying and standardizing tremor assessment. J Medical Engineering and Technology 28(6):254-62.

Cortese, L Caligiuri MP, Malla AK, Manchanda R, Takhar J, Haricharan R. (2005) Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naïve schizophrenia patients. Schizophrenia Research 75: 65-75

Caligiuri MP, Teulings HL, Filoteo JV, Song D, Lohr JB (2006) Quantitative measurement of handwriting in the assessment of drug-induced parkinsonism. Human Movement Science (4-5):510-22

Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr JB (2009) Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. Human Movement Science Oct;28(5):633-42

Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr JB (2010) Handwriting movement kinematics for quantifying EPS in patients treated with atypical antipsychotics. Psychiatry Research 177: 77-83.

Mohammed, L., Found, B., Caligiuri, M., Rogers, D (2010). The Dynamic Character of Disguise Behavior for Text-Based, Mixed, and Stylized Signatures. Journal of Forensic Sciences (in press).